Asam niflumat

Asam niflumat
Nama sistematis (IUPAC)
Asam 2-{[3-(trifluorometil)fenol]amino}nikotinat
Data klinis
AHFS/Drugs.com International Drug Names
Kat. kehamilan ?
Status hukum ?
Data farmakokinetik
Waktu paruh 2,5 jam[1]
Pengenal
Nomor CAS 4394-00-7 YaY
Kode ATC M01AX02 M02AA17
PubChem CID 4488
Ligan IUPHAR 2439
ChemSpider 4333 N
UNII 4U5MP5IUD8 N
KEGG D08275 YaY
ChEMBL CHEMBL63323 N
Data kimia
Rumus C13H9F3N2O2 
SMILES eMolecules & PubChem

  • InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20) N
    Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N N

Data fisik
Titik lebur 204 °C (399 °F)

Asam niflumat adalah obat yang digunakan untuk nyeri sendi dan otot. Ia dikategorikan sebagai penghambat siklooksigenase-2. Dalam biologi eksperimental, ia telah digunakan untuk menghambat saluran klorida.[2] Ia juga telah dilaporkan bekerja pada saluran NMDA[3] dan GABA-A[4] serta memblokir saluran kalsium tipe T.[5]

Referensi

  1. ^ "Half life". Drug Bank. Diakses tanggal 5 Januari 2024. 
  2. ^ Knauf PA, Mann NA (Mei 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658 alt=Dapat diakses gratis. PMID 6736917. 
  3. ^ Lerma J, Martín del Río R (Februari 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. PMID 1371581. 
  4. ^ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID 12920213. 
  5. ^ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (Juni 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC 4146346 alt=Dapat diakses gratis. PMID 21898399. 
Ikon rintisan

Artikel bertopik obat yang berkaitan dengan sistem muskuloskeletal ini adalah sebuah rintisan. Anda dapat membantu Wikipedia dengan mengembangkannya.

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