Antigen leukosit manusia

Antigen leukosit manusia
Representasi skematis kompleks histokompatibilitas utama kelas I
Identifikasi
SimbolHLA
InterProIPR037055

Sistem atau kompleks Antigen leukosit manusia, dalam bahasa Inggris disebut human leukocyte antigen (HLA), adalah sekelompok protein terkait yang diproduksi oleh supergen kompleks histokompatibilitas utama pada manusia.[1] Protein permukaan sel ini bertanggung jawab untuk mengatur sistem kekebalan. Kompleks gen HLA yang ada di 3 Mbp melakukan peregangan ikatan dalam kromosom 6p21. Gen HLA sangat polimorfik, yang berarti bahwa mereka memiliki banyak alel yang berbeda, sehingga memungkinkan untuk menyempurnakan sistem imun adaptif. Protein yang dihasilkan oleh gen tertentu juga dikenal sebagai "antigen", hasil dari penemuan bersejarahnya sebagai faktor dalam transplantasi organ.

Referensi

  1. ^ Reference, Genetics Home. "Histocompatibility complex". Genetics Home Reference (dalam bahasa Inggris). Diakses tanggal 2020-05-01. 


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